Mister Bitters Grapefruit Agave Bitters is a botanical spirit and is a grapefruit flavoured alcohol and is a very high price and is quite strong with ABV at 39 percent and is a spirit bitters and is made by Mister Bitters and produced in the region of Fitzroy Melbourne Victoria and made in Australia and below is a list of the best five mister bitters grapefruit agave bitters drinks.